ABSTRACT
This study was undertaken to determine the effect of Centella asiatica aqueous extract (CAEt) on nociception; experimental diabetes and hyperlipidemia in mice and rats. The extract was administered orally and the effects of different doses of the extract on nociception in mice; on blood glucose; glucose-6-phosphatase; and serum and tissue lipids in rats with alloxan-induced diabetes were studied. Diclofenac and chlopropamide were used as standard drugs for nociception and diabetes; respectively. The doses of extract administered were 150; 300; 500 mg/kg body weight. The data obtained indicated that the aqueous extract of Centella asiatica exhibited anti-nociceptive activity in mice. Results of the anti-diabetic study indicated that the extract suppressed the elevated blood glucose. In anti-hyperlipidemic study; lipid levels didn't change in diabetic rats treated with CAEt. These findings show that the extract possesses anti-nociceptive and anti-diabetic activities